The decisive moment came in the 66th minute when Le Fee composed himself to calmly roll the spot-kick into the bottom corner having been brought down at the end of a swift counter-attack. Roared on by a vociferous home crowd, the Black Cats had been much the better side in the first half of this Europa League opener but failed to take their chances - Le Fee coming closest with a shot that came back off the post. But AZ arrived boasting an unbeaten record and showed why in a much-improved second-half showing. Sunderland appeared to be clinging on in the closing stages before their Dutch opponents tired. Regis le Bris' side should have extended their lead in the final moments, but missed chances were soon forgotten as the final whistle confirmed a first victory in European competition since 1973.

United head coach Michael Carrick had to bring on skipper Bruno Fernandes 18 minutes from time in a desperate attempt to salvage the game after watching his side concede twice in four second-half minutes. It was the first time United had led at home by two goals and lost since they were beaten 3-2 by Tottenham in 1976, half a century ago. The small band of Brighton fans were jubilant as they celebrated in the corner of Old Trafford, with the home fans booing their team off at the final whistle. It was the worst possible outcome for United and Carrick, still reeling from the stunning Manchester derby defeat by 10-man City - followed by 15-year-old academy star JJ Gabriel informing the club of his intention to quit. United thought they had the perfect response when their other highly rated youngster Shea Lacey marked his first senior start with a well-taken goal after just eight minutes. Mason Mount doubled their advantage two minutes later when he drove home the rebound from a Marcus Rashford effort that had been blocked. At that point, it looked like being a good night for Carrick and his team. But Charalampos Kostoulas pulled one back just before half-time. Brighton skipper Pascal Gross levelled when he was left on his own on the edge of the area and had time to turn on to a clearance from halfway and send his shot beyond Wales goalkeeper Karl Darlow, who was making his United debut. Four minutes later, Kostoulas turned supplier as he cut the ball back for substitute Maxim de Cuyper to finish. Jason Steele denied Marcus Rashford an equaliser at one end, but United were reliant on Darlow denying Diego Gomez a fourth Brighton goal. After their humbling EFL Cup loss at League Two Grimsby last season, followed by Brighton's FA Cup triumph here in January, it was a third successive domestic cup loss for Manchester United.

The 16-year-old was one of two youngsters making their first appearance of the season from the start, alongside centre-back Marli Salmon, 17. Dowman opened the scoring with a fine solo goal in the seventh minute. He won the ball in midfield, played a one-two with Eberechi Eze and ran through, leaving two defenders on the ground, before sending the goalkeeper the wrong way. Noni Madueke rifled in their second effort following Mikel Merino's flicked ball over the top. And after the break Dowman showed good composure to control Martin Zubimendi's pass before rolling the ball into the far bottom corner. Merino fired in Arsenal's fourth goal off the inside of the post. Ipswich scored twice, through Anis Mehmeti's finish from Jack Clarke's pass and Chuba Akpom's tidy turn and finish - but it was far too little and too late. As is the norm these days, both sides put out heavily rotated starting line-ups - with a combined 19 changes from their weekend Premier League matches.

Roberto de Zerbi's team at least managed to score their first goal this season against Premier League opposition - having failed to find the net in four league games. But goals from Alexis Mac Allister, Cody Gakpo and Dominik Szoboszlai helped Andoni Iraola's Liverpool progress to the fourth round at Spurs' expense. Both managers named heavily-changed lineups with Iraola making 10 changes from the side that laboured to a goalless draw against Fulham on Saturday, with only Ronald Araujo retaining his place and Joe Gomez captaining the team on his first appearance of the season. De Zerbi made eight changes from Spurs' goalless draw against Everton with Andy Robertson on the bench on his first return to Anfield since leaving Liverpool in the summer. And, after Giorgi Mamardashvili had denied Spurs an opener with a great save from Lucas Bergvall, Liverpool broke the deadlock on 21 minutes when Mac Allister side-footed the ball into the top corner as it broke to him on the edge of the box. Spurs should have levelled shortly after the half-hour mark when Mohammed Kudus blazed over from a few yards out and Liverpool made them pay after the break as they doubled their lead when Gakpo finished off a lovely move after being set up by Mac Allister. Robertson came on to a standing Anfield ovation shortly after as De Zerbi turned to his bench and Spurs had some hope when Conor Gallagher turned the ball into the net from Mateus Fernandes' corner after 69 minutes. It was their first goal against Premier League opposition this season and their first since August 26 in the previous round. The 6,000-strong travelling support should had an equaliser to celebrate but Mamardashvili made another superb stop to keep out Omar Marmoush before Savio fired wide from inside the box. And Szoboszlai ensured a Liverpool win when he chested the ball down in injury time and found the back of the net with a Steven Gerrard-esque thunderbolt from 25 yards out. Spurs have now lost three of their six games in all competitions this season, with their only win coming in the previous round of the Carabao Cup against Charlton.

A 14-minute burst in the first half proved too much for the Magpies, with an own goal from Lewis Miley following strikes by Jayden Bogle and Dominic Calvert-Lewin, before Noah Okafor netted in the second period. Leeds now sit third on eight points - just four adrift of champions and leaders Arsenal. Daniel Farke's side needed a slice of luck to take the lead when Ao Tanaka's 32nd-minute strike took a wicked double deflection off Sean Steur and Miley before looping into the bottom corner. Just two minutes and 42 seconds later, Calvert-Lewin thought he had headed in Leeds' second but the final touch came off the top of team-mate Bogle's head for 2-0. But, a minute into stoppage time, Calvert-Lewin claimed his goal with a composed finish across Lukas Hornicek - taking his career tally against Newcastle to eight. It went from bad to worse for Newcastle in the second half when substitute Okafor slotted home Leeds' fourth of the night. Substitute Bazoumana Toure managed to find a consolation goal for the visitors in the 90th minute, but it was too little too late.