Mikel Arteta's side had dropped to second place for the first time since October after Manchester City's win against Burnley in midweek had seen them go top of the table on goal difference. Arsenal started the game well and took the lead in the ninth minute through Eze after a well-worked short corner. The England international was passed the ball on the edge of the box by Kai Havertz and curled an excellent strike into the top corner. Newcastle had chances of their own through William Osula, Bruno Guimaraes and Sandro Tonali but could not find a way to score in the first half. Eddie Howe introduced Yoane Wissa and Harvey Barnes after the break as the away side chased an equaliser. And Wissa missed a golden opportunity late on to level the match as Newcastle were defeated for the fourth league match in a row. The win moves Arsenal three points clear at the top of the Premier League having played a game more than title-rivals Manchester City. The only negative of the day for the Gunners was that both Havertz and Eze had to be substituted with injury.

Pep Guardiola's side have already lifted the Carabao Cup this season and will return to the capital on Saturday, 16 May when they will be heavy favourites against either Chelsea or Leeds United. The Spaniard made eight changes to the side that edged past Burnley in midweek and City's second string were unable to find any rhythm or create clear-cut chances in a scrappy opening period. Omar Marmoush's shot at the near post was kept out by the feet of Southampton goalkeeper Daniel Peretz, while Saints celebrations were cut short when Leo Scienza's cool finish was disallowed for offside. Southampton managed their first shot on target on 55 minutes but Ross Stewart's effort was straight into the grasp of James Trafford, while at the other end, substitute Savinho's bending strike was pushed away by Peretz. The semi-final came alive 11 minutes from time when Finn Azaz curled home an unstoppable strike into the top corner from 20 yards out to spark joyous scenes in the Saints end, but they were silenced just two minutes later when Jeremy Doku's deflected shot crept into the far corner. And with extra-time looming, Nico Gonzalez stepped up to power home a thumping strike past the reach of Peretz to turn the game around for City in their search for a third FA Cup triumph under Guardiola.

Sweden forward Isak has endured a bitterly frustrating spell since completing a British record £125m move from Newcastle. But he set Liverpool on their way to a third straight top-flight win when his shot into the ground from 12 yards looped over the head of Palace goalkeeper Dean Henderson and into the net. Liverpool's third-choice keeper Freddie Woodman made his first Premier League appearance for the Reds as Alisson and Giorgi Mamardashvili were both injured. Woodman made a diving save to keep out Jean-Philippe Mateta's header moments before Liverpool made it 2-0 through Andy Robertson. The Scotland full-back finished off a fine counter-attack with a precise finish following a lightning attack involving Curtis Jones. Palace set up a grandstand finish when Daniel Munoz scored from outside the box with Woodman down injured, before Eagles substitute Jorgen Strand Larsen hit the post in the 84th minute. But the Reds sealed victory through Florian Wirtz deep into stoppage time, a right-foot finish from inside the box.

West Ham's dramatic 2-1 win over Everton left Spurs two points from safety, third from bottom with four games remaining. Roberto de Zerbi's side looked like climbing out of the drop zone after substitute Palhinha prodded in from close range at already relegated Wolves only for Callum Wilson's strike to earn the Hammers an injury-time victory in their match. The drama was not restricted to the London Stadium as Antonin Kinsky produced a brilliant last-gasp save to keep out Joao Gomes' free kick. Spurs, who are trying to avoid a first top flight relegation since 1977, also lost Dominic Solanke and Xavi Simons to injury. The nerves from the visitors were obvious as they looked for a first top-flight win since December but they still dominated a forgettable first half, although desperately lacked quality. They had little to build on at the break and Simons wasted a good chance when he fired over after skipping past Matt Doherty before he was carried off with a knee injury. Jose Sa's fine stop denied Rodrigo Bentancur but Palhinha forced in the winner with seven minutes left and Kinsky's injury-time save from Joao Gomes sealed victory.

Vincent Kompany's men were 3-0 down at the break after the Bayern boss made nine changes from the midweek win over Bayer Leverkusen in the German Cup semi-finals, with the Bundesliga title already secured following last weekend's win over Stuttgart and with Tuesday's Champions League last-four first-leg clash with Paris St-Germain in mind. But he threw on Harry Kane and Michael Olise at the interval before Jamal Musiala also came on early in the second half and all three helped complete the remarkable turnaround. Dominik Kohr scored a tidy volley in the 15th minute from a Kaishu Sano cross to put Mainz O5 into an early lead before Paul Nebel turned home a rebound from Nadiem Amiri's saved effort. Sheraldo Becker tapped home in first-half stoppage time after Amiri had a strike tipped on to the bar by Bayern back-up keeper Jonas Urbig and it looked like the upset was on with Bayern heading for just their second league defeat of the season. But on-loan striker Nicolas Jackson started the comeback when he turned home Konrad Laimer's cross seven minutes after the restart before ex-Crystal Palace winger Olise scored a stunning second after he cut inside off the left before curling the ball into the top corner in the 73rd-minute. Olise was involved for the equaliser as he put the ball in for Musiala, who managed to bundle it over the line with 10 minutes remaining. Kane completed the turnaround in the 83rd minute after Musiala's cross was pushed into his path by Mainz 05 keeper Daniel Batz. Mainz 05, who were bottom of the Bundesliga after 13 games when head coach Urs Fischer was appointed in December, will have to wait another week to ensure they are mathematically safe from relegation as they remain eight points clear of the drop zone with three games to go.